This chapter explores the symbiotic relationship between compassion and traumainformed care, revealing a transformative interplay within social work practice. Highlighting the guiding force of compassion, it delves into how empathy, understanding, and resilience infuse traumainformed perspectives, shaping responsive and humane interventions. The case study of the Rajagiri School of Social Work exemplifies this synergy, showcasing the profound impact of cultivating compassion in addressing multifaceted traumas. By weaving together cultural competence, and trauma-informed principles, the chapter serves as a comprehensive guide for practitioners, emphasizing the pivotal role of compassion in reshaping the social work landscape. Ultimately, it underscores the enduring significance of cultivating compassion as a foundational element, illuminating a path toward positive change, empowerment, and transformative healing within trauma-informed social work practice.