Bromelain is a type of proteolytic enzyme derived from either the pineapple fruit or stem and is commercially available. These two, fruit bromelain and stem bromelain have differing enzymatic components and are prepared differently. Its minimal toxicity, high effectiveness, easy accessibility, and simple procurement make it an endlessly attractive subject for researchers. The new therapeutic benefits of bromelain include promoting wound healing, enhancing drug absorption, and managing conditions such as sinusitis, bronchitis, angina pectoris, surgical trauma, and thrombophlebitis. Additionally, it has been proven to be effective in treating cardiovascular diseases, diarrhoea, and osteoarthritis. Bromelain also induces apoptotic cell death and displays anti-cancer properties. This review aims to provide an overview of Bromelain's uses and its potential applications.